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Gene expression is traditionally viewed as a linear process divided into distinct stages. We have shown that this view is oversimplified. First, RNA polymerase II controls mRNA translation and decay via a mediator, Rpb4/7. Second, many transcripts are "tagged" with factors co-transcriptionally, one of these tags being Rpb4/7, which later regulate mRNA localization, translatability, and decay. We term this tagging "mRNA imprinting." Recently, we discovered that ~50 proteins bind Pol II transcripts co-transcriptionally, many of which likely affect mRNA fate. Remarkably, promoters, DNA elements […]
CRISPR-Cas systems are adaptive immune systems found in bacteria or archaea that protect against the invading of mobile genetic elements (MGEs), such as phages and plasmids. To defend against foreign nucleic acids, CRISPR-Cas systems capture short DNA segments from invaders and insert them into the CRISPR array, thus recording a genetic snapshot of potential threats. The CRISPR locus is then transcribed and processed to generate CRISPR RNA (crRNA) that binds and guides the Cas protein effector complex to cleave the genome of the invader when it returns. To counteract CRISPR-Cas systems, […]
Jewel-like memories
Structure and mechanism of a methyl transferase ribozyme
Computational modeling of RNA 3D structures and interactions with the use of experimental data
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Prof. Mordechai (Motti) Choder, Technion – Israel Institute of Technology, Israel, will give a talk on A system view of gene expression: cross talks among all stages of the mRNA life.
Gene expression is traditionally viewed as a linear process divided into distinct stages. We have shown that this view is oversimplified. First, RNA polymerase II controls mRNA translation and decay via a mediator, Rpb4/7. Second, many transcripts are "tagged" with factors co-transcriptionally, one of these tags being Rpb4/7, which later regulate mRNA localization, translatability, and decay. We term this tagging "mRNA imprinting." Recently, we discovered that ~50 proteins bind Pol II transcripts co-transcriptionally, many of which likely affect mRNA fate. Remarkably, promoters, DNA elements known to control transcription, also regulate "mRNA imprinting," thereby influencing mRNA fate in the cytoplasm. Third, we found that the major mRNA 'decaysome', known for degrading mRNAs in the cytoplasm, also functions as a transcription activator by physically associating with chromatin. Significantly, the decaysome's ability to function in the synthesis of a particular mRNA in the nucleus depends on its capacity to complete degrading this mRNA in the cytoplasm. The underlying mechanism will be discussed in my talk. I will propose that some mRNA synthesis and decay factors represent a novel class of factors, "mRNA coordinators," which shuttle between all complexes controlling the mRNA lifecycle, integrating them into a system. I will show that Rpb4/7 carries >100 combinations of temporal post-translational modifications, which respond to the stage of the mRNA/Rpb4/7 complex (e.g., mRNA synthesis, translation, decay) and to the environment. We propose that these modifications are components of the language by which the various stages communicate and function as a system.
For more information about her outstanding work, please visit her profile at
https://graduate.technion.ac.il/wp-content/uploads/Moti-Choder.pdf
Time (China): 2025-2-17 16:00
Zoom meeting: 893 0005 4861
Passcode: 123456
Zoom meeting link:
https://us06web.zoom.us/j/89300054861?pwd=TZbjJuSwrz4lTdg8yKCwDKKDDzqwNe.1
bilibili live link:
https://live.bilibili.com/26427894
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Thanks to the International RNA Society, 表观生物, 博奥龙, 新使生物 and LEXOGEN for their sponsorship support!
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Based on the applications of the pre-conference participants, 13 students have been awarded 2023 RNA Society trainee memberships for free. It is great to see the participation of students from different institutions, such as Lanzhou University, Nankai University, SIBS, Shanghai Jiaotong University, Melbourne University, Guangzhou Medical University, ShenZhen Bay Laboratory, Sun Yat-sen University and so on.
根据前期会议参与同学申请情况，13位同学已免费获得 2023 RNA Society trainee memberships。很高兴看到不同单位的同学申请，兰大，南开，SIBS，上交，墨尔本，广医，深圳湾，双鸭山等等。
We are organising RNA-Puzzles, which is a community-wide blind assessment of RNA 3D structure prediction. We also work on AI-based RNA design and RNA virus related research.
My lab is interested in the structure and function of nucleic acid aptamers, riboswitches, protein-nucleic acid interactions and catalytic activity in nucleic acids.
My research interests focus on the development and application of experimental and computational methods to discover novel classes of ncRNAs and their functions and mechanisms.
We are interested in eluciding the mechanisms and regulatory roles of RNA modifications on different classes of RNAs through close integration of bioinformatic method development with biochemical experiments.
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